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When the dose is taken with food and also total availability of misoprostol acid is reduced by use of concomitant antacid, Maximum plasma focus of misoprostol acid are decreased. Clinical trials were carried out with concomitant antacid, nonetheless, so this result does not seem medically crucial.



After dental management of radiolabeled misoprostol, about 80 % of detected radioactivity appears in urine. Pharmacokinetic research studies in individuals with varying degrees of renal impairment revealed an approximate increasing of AUC, t1/2, and cmax compared to normals, but no clear relationship between the level of disability and also AUC. In subjects over 64 years old, the AUC for misoprostol acid is enhanced. No regular dose modification is recommended in older clients or patients with kidney disability, yet dose may have to be minimized if the common dosage is not put up with.



Drug communication studies between misoprostol and a number of nonsteroidal anti-inflammatory medications revealed no result on the kinetics of ibuprofen or diclofenac, and a 20 % reduction in aspirin AUC, not thought to be clinically significant.



When these medicines were provided with misoprostol, pharmacokinetic researches additionally revealed an absence of drug interaction with antipyrine and propranolol. Misoprostol given for 1 week had no effect on the stable state pharmacokinetics of diazepam when the two medications were administered 2 hrs apart.



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